Over 80 clinical trials launched to test treatments for coronaviruses

China has more than 80 clinical trials underway on potential treatments for COVID-19, the disease caused by a coronavirus that has so far killed nearly 1,400 people and infected more than 48,000 across China .

New pharmaceutical drugs are listed alongside traditional millennial therapies in a public registry of clinical trials in China, which is growing daily. There is no known cure, and doctors are keen to help people with the disease, but scientists warn that only carefully done tests will determine which measures work.

Soumya Swaminathan, Chief Scientist of the World Health Organization (WHO), says its teams have taken stock of the many trials in China, as well as the development of a plan for a clinical trial protocol which could be administered simultaneously by doctors. If the Chinese trials, which include up to 600 people each, are not designed with strict standards for study parameters, such as control groups, randomization, and clinical outcome measures, efforts will be in vain. WHO is therefore working with Chinese scientists to establish standards from the start. For example, a person’s recovery or decline stages should be measured in the same way, regardless of the treatment tested. “We hope we can bring some sort of structure to the whole,” says Swaminathan.

The WHO clinical trial protocol is designed to be flexible and allow researchers around the world to pool their results over time. He will compare two or three therapies supported by scientific evidence, including a combination of HIV drugs (lopinavir and ritonavir) and an experimental antiviral called remdesivir.

China has already started trials on the drugs that will be included in the WHO master plan. The Chinese Register of Clinical Trials, a database of biomedical studies in China, lists these surveys among dozens of other controlled trials on existing therapies, experimental procedures and traditional medicines. These treatments have different amounts of evidence that support their effectiveness.

Both anti-HIV drugs block the enzymes that viruses need to replicate. In animal studies, they reduced the levels of coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) 1. Remdesivir, a nucleotide analogue manufactured by biotechnology company Gilead in Foster City , California, has also had some success against coronaviruses in animals2. In January, researchers reported that someone in the United States had survived COVID-19 infection after being treated with remdesivir3. In the first week of February, China launched two placebo-controlled trials of remdesivir, which are expected to include 760 people with COVID-19. The studies are expected to be completed by the end of April and the remdesivir could be approved by the Chinese authorities as early as May, said Shibo Jiang, a virologist at Shanghai Fudan University. “But the epidemic could have disappeared by then,” he said.
China has launched trials to test chloroquine, a malaria drug that has eliminated the new coronavirus (recently called SARS-CoV-2) in cell culture4. And researchers are studying whether steroids reduce inflammation or cause harm to people with severe COVID-19. “It will be interesting to see these results”, explains Yazdan Yazdanpanah, epidemiologist at INSERM, in Paris. Clinical researchers around the world will need this information if the epidemic continues to spread, he added.

Another study, a controlled trial of 300 people, will analyze the serum of COVID-19 survivors. The basic strategy, based on the idea that the antibodies a person constantly builds up to fight a virus can quickly help a newly infected person to fight it, has been modestly successful when used to treat others viruses in recent decades.

Two stem cell trials are also listed in the Chinese registry. In one case, a team from the first affiliated hospital of Zhejiang University will inject 28 stem cells derived from menstrual blood and compare the results with those of people who did not receive the infusions. So far, there is little evidence that stem cells kill coronavirus infections. Swaminathan says WHO can’t control what researchers do, but says the agency published a guide to the ethics of conducting trials in epidemics in 2016. And it will soon publish a brief report and more accessible on the subject.

Fifteen trials included in the Chinese registry plan to enroll more than 2,000 people in total in studies on a variety of traditional Chinese medicines. One of the most important evaluates shuanghuanglian, a Chinese herbal medicine that contains extracts of dried fruit lianqiao (Forsythiae fructus), which has been used to treat infections for more than 2000 years. The trial had 400 participants, including a control group who received standard care but not placebo therapy.

WHO is working with Chinese scientists to standardize the design of all studies, including those of traditional medicines. The efforts come from a controversial movement last year, in which the organization recognized traditional Chinese medicine in its collection of diseases. Critics have argued that recognizing WHO equals support, but Swaminathan disagrees. She says the WHO measure helps the organization to code medical terminology so that herbal remedies can be assessed with the same rigor expected from pharmaceutical tests. “We want a scientific approach to try traditional medicine,” she says.

As these trials take off, researchers are looking for new drugs that fight multiple coronaviruses, including those that have not yet appeared. A peak protein on the surface of the viruses underlying SARS, MERS and COVID-19 provides a tempting goal. Already, Jiang and other research groups have found compounds and antibodies that project onto this pic6, which could prevent coronaviruses from invading human cells.

With many therapeutic options and a limited time, the WHO should provide advice on which treatments to advance and which to discontinue as trials progress.

Total Body Enhancement Planet Fitness: Everything You Need To Know

Total body enhancement planet fitness

Total body enhancement planet fitness is a machine or a cabin that offers a red light therapy combined with body vibrations to reshape the body, improving skin conditions and burning body fat.

  • Red light therapy is a method that exposes the skin to red light to activate ATP, also known as adenosine triphosphate. When ATP is released, your muscles gain more energy and allow you to train longer or harder. Red light therapy also reduces cellulite. It is also used to treat wounds faster and to reduce the prevalence of acne.

If you are a regular member of Planet Fitness, you have probably used the Total body enhancement planet fitness machine several times to improve your body. 

So what is the total body enhancement at planet fitness?

It is a machine used by Planet fitness for the improvement of skin conditions, reshaping the body and burning fats. This machine uses red light therapy along with Vibration. Red Light Tan Therapy is the latest craze in the tanning salon. The Vibration helps relieve tension in your muscles and joints, and the levels of vibration help with cellulite. The red light Increases the collagen in the skin, reducing the appearance of cellulite and wrinkles in the body. The vibrating plate helps improve circulation and strengthen your core. The Total body enhancement machine is also called the beauty Angel.

Now the question is.

Is it safe to use total body enhancement planet fitness machine?

Yes, it uses the red light therapy with non-damaging, non-UV rays, which means you don’t need to worry about hurting your skin or increasing your risk of skin cancer when you use the Total Body Enhancement machine.

According to a study, Light therapy doesn’t cause any harmful effects on tumor growth. This study suggests that cancer patients should not retain Low-level light therapy on an empirical basis.

Now the next question is.

How Total Body enhancement Planet fitness machine Work?

Planet Fitness is one of the most popular gyms, with the right attitude and a friendly and non-critical attitude. It is an excellent place for people who want to lose weight or improve their tone. Planet Fitness requires registration at different levels. In return, you will have access to various sports equipment, free physical training, hydro massage chairs, tanning beds, and your light therapy cabin.

Red Light Therapy: This red light therapy, along with the vibration machine, also known as the angel of beauty, is a relatively new addition to the Planet Fitness range. It looks a lot like a tanning booth, but the similarities stop there. Instead of UV lamps, it uses infrared lamps that affect the entire body. Red light uses low levels of wavelengths to treat skin problems such as wrinkles, scars and permanent wounds, and other conditions.

Health Benefits Of Red Light Therapy


Vibration: Along with Red light therapy, it also uses Vibration. The vibrating base plate shakes your entire body with slight vibrations, resulting in an alternative muscle contraction and relaxation several times per second. This helps to speed up metabolism, burn excess fat, and strain the body. Watch the video below for more information.


How often can you use the total body enhancement fitness to improve the health?

You can use total body enhancement machine whenever you like. manufacturers recommend using the help 2-3 times, for 12 minutes over a 90-days period and leave 24 hours between the sessions.


Total Body Enhancement Pros and Cons

Here is a list of total body enhancement Pros and cons. If you are thinking of joining the planet fitness gym, you should read this first.

Pros of Total Body Enhancement Planet Fitness


Below are some benefits of using planet fitness total body enhancement machine.

1. Total Body Enhancement Planet Fitness helps to reduce stress.

When you’re stressed, your muscles tend to get tired. Physical or emotional stress interferes with cellular energy pathways. You should know that the improvement of the whole body takes into account your entire body to activate it for better functioning. Therefore, it is better to relieve stress by relaxing the muscles and calming the mind.

2. Total Body Enhancement Planet Fitness helps increase skin elasticity by producing collagen.

Collagen is a structural protein that plays a role in the elasticity and firmness of the skin. But with age, collagen naturally decreases, causing wrinkles, marks, and wrinkles more noticeable on the face.

Red light therapy makes the skin more elastic by increasing collagen levels in the body. Therefore, an increase in collagen is likely to produce an anti-aging effect, reducing wrinkles, stretch marks, fine lines, acne spots, and scars. This machine deserves your time and attention because it helps you get better, fresh, and radiant skin.

3. Reduce the weight by decreasing cellulite

The vibrating plate of the Total Body Enhancement Planet Fitness machine serves to rejuvenate your body by sending energy everywhere. It helps you work your legs, abs, arms, and buttocks (hip muscles). Cellulite is an irregular and stuffed meat, especially in the thighs, buttocks, and abdomen. This unwanted cellulite is very frustrating.

Red light therapy extends its benefits by reducing cellulite around the waist, hips, and thighs. This is because the fat cells overflow with their content, and the body processes the expelled fat. Therefore, this therapy is ideal for reducing body circumference measurements significantly.

4. Total Body Enhancement Planet Fitness helps improve metabolic rate and energy levels.

Total body improvement accelerates the body’s metabolism by stimulating the production of mitochondrial ATP (adenosine triphosphate, the energy currency of the cell). It also allows you to gain more energy before training. The improved metabolism serves to release the fat stored by the cells (adipocytes). Washing unnecessary fat will make a good breakthrough.

5. It reduces inflammation of the joints and muscles.

It has been shown that Red Light Therapy heats a joint to improve the body in general, making it more flexible, mobile, and easy to use.

Improving blood circulation also relieves joint pain by significantly reducing inflammation. This suggests that it is a powerful method for rapid wound healing.

Cons Of Total Body Enhancement Planet Fitness:


1. Need Membership Black Card

You must be a member of a black card to take full advantage of the benefits of improving your body and your pleasure. To get the most out of the Planet gym and improve your training experience, you’ll need a $ 21.99 card per month.

2. Allergies

You can’t use total body enhancement planet fitness machines if you are allergic. Allergic reactions like skin rashes, itching, nausea, etc. may occur, so avoid if you are allergic.

3. Cough: The Vibration and light can sometimes cause coughing.


How do you use Total Body Enhancement at Planet Fitness?

Here are some tips which you should keep in mind before using Total body enhancement at the planet fitness machine.

Here we go

These are the steps to apply Total Body Enhancement correctly:

  • Press the start button on the remote control.
  • Activate the vibrating pad (symbolized by an icon in the upper left of the remote control) by pressing the white button to the left of the remote control (one of the four white buttons). Be sure to press the button twice, and you will notice that the foot icon is flashing.
  • So it’s time to choose the vibration intensity program. There are four programs to choose from. Press the upper white button (with a +) to scroll through the options.
  • After selecting the vibration setting for the foot, release the LED display to clear.
  • Now is the time to focus on the fan and the icon in the upper right corner of the remote control.
  • Double-tap the white button on the right side of the remote control until the fan light comes on.
  • As soon as the light comes on, you can use the white button at the top (with the + sign) to adjust the fan speed. If it goes up around 11, keep calm on the whole body strengthening machine.

The instructions for using the Total Body Enhancement device are quite simple after learning them. Knowing them beforehand, you will surely get into the machine and enjoy the benefits.

How often should you use total body enhancement?

It depends on various factors, as everyone reacts differently according to age and skin condition. In general, the best results are obtained in a period of 8 to 12 weeks.

It is recommended to start 3 to 5 times per week for the first 1 to 4 weeks with a contact time of 15 minutes. It is the maximum exposure duration in our red light therapy bed. Subsequently, it is necessary to use the red light therapy bed at least 2-3 times per week for 4-12 weeks and finally 1-2 times per week to obtain the desired results for the skin.

Total Body Enhancement Programs

The client can choose between four different programs. The intensity and duration of each program can be adapted to individual needs.

Program No. 1.

  • Low intensity: This is the “Feel Great” program. This program improves flexibility, relaxes muscles with smooth movements with low vibration frequency.

Program No. 2

  • Medium intensity: This is called the “New You” program. This program is for beginners. The program number 2 is ideal for people who want to start or return with their fitness program. This medium intensity program uses medium frequency vibrations and massages to improve the appearance of muscle tone through alternate controlled movements.

Program No. 3.

  • High intensity: This program is the “Cross Training” level. The program number 3 uses intense vibrations in combination with high-frequency interval training. It is a balanced program that strengthens muscles with powerful movements. This program is perfect for athletes or sports enthusiasts.

Program 4

  • Mixed Intensity: This mixed frequency cycle is aimed at specific muscle groups of arms, legs, abdomen, and buttocks. It helps tone and tone the muscles and provides stimulating training.


You should use Total Body Enhancement at planet fitness frequently and consistently to achieve long-term benefits and achieve the desired results. Do not be discouraged if you do not notice anything after a single-use. As you continue to use the unit over time, you will see gradual changes in different ways.

What to do if sore throat does not heal?

It’s hard to find someone who has never had a sore throat in their lives. Treating with scratches, itching and burning is never fun, but it gets even more annoying if these symptoms do not disappear. Most people find relief in caring for their family, but others will continue to feel unhappy. Read on to learn more about the causes of sore throats that do not disappear and what you can do to fix them.


Sore throat does not heal, why?

There are several reasons why you may have a persistent symptom of sore throat. Here are some for your understanding:

1. Viral causes

You may have a viral infection that makes you unhappy, and the two most common are colds and mononucleosis.


Colds start with a symptom, but it gets worse. Symptoms as they occur

  • Cough
  • Eyes full of tears,
  • Sneeze,
  • A mild headache,
  • Moderate temperature e
  • Muscle aches.

Sore throat is often associated with these symptoms.

  • A cold usually takes a few days to a week, but the cough may last for several weeks. When you feel cold, you can develop a type of asthma in the chest that forces people to gasp, which can be relieved by inhalers.


The sore throat that does not disappear may be due to a mononucleosis. It hits you for at least 10 days, but you may feel weak for 12 weeks. You will also notice other symptoms, such as:

swollen and
Painful armpits,
Lymph node e
You can also have a swollen liver


Liquids, rest and anti-inflammatory agents relieve the symptoms a bit.

2. Bacterial causes

The sore throat may be due to a bacterial infection. This may be due to a sore throat or tonsillitis.

Streptococcal pharyngitis:

Symptoms such as inflammation of the cervical glands, fever and white spots in the tonsils occur. You will not have a cough. The sore throat suddenly hits you and makes your throat turn red.


A bacterial infection can cause swollen tonsils with or without white spots. It may be necessary to remove the tonsils if angina occurs several times a year. Typical symptoms of tonsillitis are

  • Fever,
  • Chills,
  • Difficulties swallowing
  • Sore throat,
  • Earache,
  • Loss of items e
  • Bad breath.

3. Other causes

In addition to bacterial and viral causes, many other causes can cause a sore throat.
Reflux: Sore throat can be caused by reflux, a condition in which acid or food accumulates in the esophagus. In this case, you can avoid spicy food and take small meals.
Allergies: The most common allergic symptom is a
• Runny nose with a blocked nose.
• stuffy nose
• can also cause headaches that worsen at bedtime.

Contact with dry air or smoke:

Working in a dry air or tobacco smoke environment can also cause a sore throat that does not disappear.

How to relieve sore throat that does not heal?

You can try some home remedies and tips to relieve sore throat. These agents may or may not work depending on the exact cause of the sore throat. However, it is helpful to use these home-based caregiving for relief.

  • Gargle with salt water. Simply add salt to a cup of water and gargle. This relieves the discomfort associated with sore throat.
  • The use of a pill may also be useful as it contains menthol which anesthetizes the tissue of the pharynx. However, the pills will bring temporary relief.
  • Do not give baby pills as they may cause suffocation.
  • Add honey to the normal tea and drink it slowly to relieve the disgruntled neck. Honey is also a cough medicine, so you can use a drop at the next throat-tickling.
  • Provide enough water if you have a sore throat that does not disappear. Drinking water helps to lubricate the neck and relieve inflammation.
  • Have you installed a humidifier in your room if you still have an irritated neck? The humid air calms the inflamed tissues of the throat and nose. A humidifier humidifies your room and provides moist air to relieve dry throat. Take a steam shower. It is an excellent alternative for spending time in a room equipped with a humidifier. Open the hot water of your bathtub and stay away for a moment. Then enter your bathroom and take a deep breath. You can also fill a sink with warm water and inhale steam to relieve sore throat.
  • Try over-the-counter analgesics to fight viral infections. Aleve and Advil are anti-inflammatory drugs that relieve pain.
  • Take antibiotics to relieve yourself. If other medicines do not work and you have a bacterial infection, you should take antibiotics to relieve yourself. Penicillin and erythromycin are the most common options here. Antibiotics are effective when the cause of the pain is sore throat. Make sure you stop the entire cycle of your antibiotics and do not stop, even if you feel better after a few days.
  • Consult your doctor if your sore throat gets worse after all other home care. The doctor monitors the symptoms and helps diagnose the cause of the sore throat to correct the problem.

Pliva 433 Pill: Uses, Side Effects, Dosage and FAQs

Pliva 433

Pliva 433 is essentially a footprint on a pill that is white in a round shape. The pill contains trazodone hydrochloride as an active ingredient in a dose of 50 mg. Pliva 433 is an antidepressant that belongs to the class of antidepressants called phenylpiperazines. It is used to treat diseases such as depression, insomnia and fibromyalgia.

It works to balance the chemicals in the brain. The Pliva 433 pills are biconvex on one side and cut in half and join on the other side.

Pliva 433 Uses

Trazodone is an antidepressant and is most commonly used in depression. It was
approved by FDA in 1981.

  • Depression
  • Anxiety
  • Fibromylagia
  • Mood disorders
  • Insomnia
  • Sedation

Note: Pliva 433 (Trazodone)  may also be used for conditions other than those listed


Side Effects

Common side effects associated with the use of Trazodone Hydrochloride (Pilva 433
Pill) are :

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Tiredness
  • Blurred vision
  • Changes in your weight
  • Headache
  • Dry mouth
  • Bad taste in the mouth
  • Muscle pains
  • Stuffy nose
  • Constipation
  • Change in sexual desire or/ and ability

Serious side effects can also occur with Pliva 433 Pill. If you have any of these side
effects, stop taking and call your doctor right away:

  • Ringing in the ears
  • Blood in urine
  • Tremors
  • Nightmares
  • Rash
  • Problems urinating
  • Fever
  • Sore throat
  • Stomach or abdominal pain
  • Shortness of breath
  • Fainting
  • Chest pain
  • Widened
  • Irregular heartbeat
  • Trouble breathing
  • Seizures
  • Vision changes
  • Severe dizziness
  • Eye pain or swelling redness


Before using Pliva 433 Tell your doctor if you have the following conditions

  • If you allergic to this drug.
  • Low or high blood pressure
  • Heart problems
  • History of substance abuse
  • Cancer
  • Mental health disorders
  • Liver problems
  • Diarrhea or vomiting
  • Kidney problems
  • Bipolar disorder
  • Glaucoma
  • Having a history of suicide
  • The risk of suicide is greatest when starting treatment or when increasing or decreasing
    the dose of trazodone.


Pliva 433 Interaction

Types of drugs that are known to interact with trazodone include:

  • Drugs used to treat mental illness, including thioridazine; selective serotonin reuptake
    inhibitors (SSRIs), and MAOIs.
  • Blood thinners, including warfarin, aspirin, and ibuprofen
  • Diuretics
  • Cold, cough, and allergy medications, including dexamethasone.
  • Medications used to treat fungal diseases, such as ketoconazol, itraconazole.
  • Medications used to treat heartburn, including cimetidin and cisapride.
  • Medications used to treat HIV/AIDS, including atazanavir, indinavir, and nelfinavir.
  • Some antibiotics, such as clarithromycin and erythromycin.
  • Some seizure medications, such as carbamazepine, ethosuximide, phenobarbital, and
  • Some heart medications, including sotalol and verapamil


Here are some dosage recommendations

  • The usual recommended  dose for depression is 150 mg daily. However, in some cases
    your physician/doctor may start with a lower dose of 100 mg to reduce the risk of side
  • The usual recommended dose for anxiety is 75 mg daily.
    If your dose is 300 mg daily or less, your doctor will probably tell you to take the single dose
    at bedtime.
  • Since Trazodone can make you sleepy, it can be helpful during sleep if you have sleep

Frequently Asked Questions (FAQs)

1. What is Pliva 433 Pill?

Pliva 433 is basically an imprint on a tablet of Trazodone hydrochloride. And it is
commonly used in depression.

2. What is Pliva 433 Pill used to treat?
It used in the treatment, control and prevention of various medical conditions such as
depression, mood disorders, mental health issues, insomnia and other conditions.

3. How Pliva 433 Pill works?
Trazodone binds to the 5-HT2 receptor, acts as a high-dose serotonin agonist and as a
low-dose serotonin antagonist. As with fluoxetine, trazodone’s antidepressant activity is likely due to the blockade of serotonin reuptake due to inhibition of the serotonin reuptake pump at the presynaptic neuronal membrane.

4. What are the side Effects of Pliva 433 pill (Trazodone Hcl) ?
The most common side effects associated with the use of Trazodone are Nausea,
Vomiting, Diarrhea, Drowsiness, Dizziness, Tiredness, Blurred vision, Changes in your
weight, Headache, Muscle pains and other. Please check above.

5. Is PLIVA 433 pill safe during pregnancy?
PLIVA 433 Pill should be used during pregnancy only if the benefits outweigh the risks
to the fetus. Trazodone is classified in the FDA Pregnancy Category C. This means that
withdrawal symptoms should be monitored in neonates if the drug is used until delivery.

6. Is the Pliva 433 pill safe while breastfeeding?
Limited data indicate that the level of trazodone in milk is low and no side effects are
expected in the breastfed infant, particularly if the infant is older than 2 months or if
doses of 100 mg or less are administered at bedtime.

7. What happens if you overdose a pill of Pliva 433?
Overdose is possible with almost all drugs, including trazodone. An overdose of
trazodone would mean that someone accidentally or intentionally ingested more than
the amount prescribed or recommended. If you have an overdose of Trazodone, it is
important to seek help immediately as this can be extremely dangerous.

8. What should you do if you miss a dose of Trazodone HCL?
Take the missed dose as soon as you remember, and when taking the next dose, skip
the previous dose.

9. Is Pliva 433 a habit forming medicines?
There is no evidence that Trazodone is addictive. However, additional side effects may
occur if you suddenly stop taking it.

10. How do I take it?
You should take Trazodone after meals to reduce the risk of getting sick.

11. Is it safe to drive a vehicle or operate machinery after taking this medicine?
Trazodone can make you sleepy or less alert. Do not drive, ride a bicycle, or use tools
or machines until you know how this medicine affects you.

12. Can Pliva 433 also be used with alcohol?
You can drink alcohol while you are taking Trazodone, but it can make you tired.
It is best if you stop drinking alcohol until you know how you feel about the medicine.